Higher Coated-Platelets in Patients with Mild Traumatic Brain Injury Correlate with Lower Cognitive Screening Performance (P3.049)
Bibliographic record
Abstract
OBJECTIVE: To examine parameters associated with elevated coated-platelet synthesis in patients with mild traumatic brain injury (mTBI). BACKGROUND: Coated-platelets are procoagulant platelets observed upon dual-agonist stimulation with collagen and thrombin. In normal controls, coated-platelet levels represent 30% of the entire platelet population. In a previous study, prompted by recent data showing an increased risk for ischemic stroke following TBI, we found that coated-platelet levels are persistently elevated in patients with mTBI several years post injury compared to controls (Prodan et al., Journal of Head Trauma Rehabilitation, in press, 2013). We now investigate if any of the parameters commonly recorded in TBI are related to coated-platelet measurements. DESIGN/METHODS: Coated-platelet levels were determined in 68 veterans with a diagnosis of mTBI based on published criteria. The time elapsed since the last injury was 6.0±2.6 years (mean±SD). Correlations were calculated between coated-platelet levels and study parameters including: age, gender, race/ethnicity, loss of consciousness, number of injuries, injury mechanism (blast versus non-blast), time since injury, post-traumatic stress disorder, medications that may influence coated-platelet levels, current smoking and presence of hypertension and diabetes. Patients underwent cognitive and depression screening using the Montreal Cognitive Assessment (MoCA) and BDI-II tests. Significance was set at 0.05. RESULTS: Mean coated-platelet levels were 51.0±13.0 (mean±SD), consistent with prior findings. A significant inverse correlation between coated-platelet levels and MoCA scores was noted when controlling for smoking, hypertension and race/ethnicity (r=-0.34, P=0.006), with lower cognitive scores observed in those with elevated coated-platelet levels. None of the other parameters studied approached significance. No significant change in coated-platelet levels was noted at 6-12 months from initial measurements (P=0.85). CONCLUSIONS: Higher coated-platelet levels correlate with lower cognitive screening scores as measured by the MoCA test in mTBI patients. Additional studies aimed at determining the long-term impact of these findings in veterans with TBI is warranted. Study Supported by: Clinical Science Research & Development Service of the VA Office of Research and Development (Award number1I01CX000340).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".