Neonatal circumcision and invasive squamous cell carcinoma of the penis: a report of 3 cases and a review of the literature
Bibliographic record
Abstract
A 55-year-old man presented with a nonhealing lesion on his glans penis that had not responded to steroid creams.He was circumcised as an infant but had a history of penile warts 25 years earlier.He was a former smoker and denied any high-risk sexual behaviour.There was no history of trauma to the penis, but he had attributed the lesion to friction induced by bike shorts.On examination, an erythematous lesion measuring 1.5 cm × 2.4 cm was present on the ventral surface of the glans near the urethral meatus.The depth of the lesion was 2-3 mm.Biopsy, performed 18 months after the onset of the symptoms, revealed a moderately differentiated squamous cell carcinoma.In situ hybridization did not detect HPV DNA in the biopsy specimen.There was no clinical evidence of inguinofemoral lymphadenopathy (T1N0).The patient was treated with interstitial brachytherapy in April 2002.Abdomino-pelvic CT scan in May 2002 showed a 3.0 cm × 1.3 cm lymph node in the right inguinal region.The patient underwent bilateral superficial inguinal dissection in June 2002, but all the lymph nodes were negative for malignancy.Four years after the procedure, he was disease-free with good cosmesis and sexual function. Case 2A 49-year-old man presented with a 6-month history of ulceration of his glans penis, which was treated with antiviral, antifungal and antibiotic agents without response.He developed a deviated urinary stream, and in November 2001 underwent biopsy, which showed diffuse inflammation of epidermis and presence Neonatal circumcision and invasive squamous cell carcinoma of the penis: a report of 3 cases and a review of the literature
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.006 | 0.005 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".