Primary diffuse large B-cell lymphoma associated with clonally-related monoclonal B lymphocytosis indicates a common precursor cell
Bibliographic record
Abstract
Bone marrow monoclonal small B-cell infiltration (MSBC) associated with monoclonal B lymphocytosis (MBL), is present at a higher frequency in patients with diffuse large B-cell lymphoma (DLBCL). We have prospectively collected blood and bone marrow (BM) samples in patients with primary DLBCL at diagnosis to study the clonal relationship of MBL/MSBC with the paired DLBCL. MBL/MSBC were detected in 6 of 19 patients, of whom 5 presented DLBCL with activated Bcell origin (ABC) and one germinal center B-cell (GCB) origin. MBL/MSBC were clonally related to the paired DLBCL in 3 of 6 patients, as demonstrated by rearranged immunoglobulin heavy chain gene sequence analysis. MBL/MSBC in these 3 patients showed a chronic lymphocytic leukemia (CLL)-like, a non-CLL-like and a germinal center cell-like immunophenotype, respectively. The former two MBL/MSBC immunophenotypes were associated with DLBCL-ABC, and the latter with DLBCL-GCB. Similar, but not identical, rearranged immunoglobulin genes were demonstrated for the 3 patients with MBL/MSBC and paired DLBCL and these were not clonally related. These results suggest that a subset of DLBCL may arise from MBL/MSBC.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.003 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".