Bibliographic record
Abstract
Dear Editor, It was with great sadness that we learnt of the death of Prof Barrie Jones on 19 August 2009 in Tauranga, New Zealand, aged 88. He was admired worldwide for his work in developing the concept of prevention of blindness and for establishing the International Centre for Eye Health (publishers of the Community Eye Health Journal) in 1981. He was in fact responsible for encouraging the launch of the first issues of this journal. However, your readers may not be aware of his major contributions, earlier in his career as first clinical professor of ophthalmology in the University of London, to the science and management of corneal and external eye disease. Barrie first addressed the range of virus infections of the eye seen in London, writing about adenovirus infection and corneal involvement by the vaccinia virus. He conducted much laboratory research on herpes simplex infection, and randomised trials of interferon, idoxuridine, trifluorothymidine, adenine arabinoside, and ultimately acyclovir. A rational approach was developed to the management of different stages of herpetic keratitis, including mechanical debridement, when to use corticosteroids, and the role of corneal grafting.1 Barrie Jones, after his retirement, discussing the progress of the clinical trial of ivermectin with Prof Adenike Abiose. NIGERIA Although a much less common cause of keratitis than in tropical countries, fungi nonetheless caused serious corneal infections in London. Barrie and his colleagues cultivated and tested the sensitivity of every fungus isolate to many different potential new drugs. He emphasized that the variations in sensitivity within each species were so great that it was necessary to base rational therapy on the results of sensitivity testing of each patient's own fungus.2 Barrie Jones was widely known as an authority on many aspects of trachoma. He developed methods of isolation, culture, and laboratory diagnosis. In extensive field studies in Tunisia, Iraq, and Iran he elucidated the seasonal dynamics of transmission of blinding hyperendemic trachoma, recognising the importance of multicyclic re-infection and the role of flies in transmission in these countries. He carried out trials of early potential vaccines and of chemotherapy.3 He investigated and wrote about an astonishing range of other corneal conditions, including infections by amoebae, vernal and other allergic types of keratoconjuntivitis, Thygeson's superficial punctate keratitis, pemphigoid, and dry eye syndromes. In the operating theatre, he pioneered new surgery of the lacrimal canaliculi and duct and improved the techniques, postoperative management, and outcomes of corneal grafting. When, around 1980, he turned the full energy of his thinking to the questions of blindness prevention, it was informed by this rich background of laboratory and clinical experience.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.024 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.004 | 0.004 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.006 | 0.011 |
| Insufficient payload (model declined to judge) | 0.037 | 0.032 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".