Study of the anti-angiogenic effects of cardiolipin by the aortic ring assay
Bibliographic record
Abstract
Cardiolipin (CL), a phospholipid found in the inner mitochondrial membrane in all cell types, is critical for the function of the electron transport chain. The role of CL is not fully understood, but it is assumed that the molecule maintains membrane potential and architecture and compensates for alterations in homeostasis that could affect the energy metabolism. The objective of this project was to determine the effects of increasing CL concentrations on angiogenic sprouting by using the aortic ring assay model. For this, 5-day-old C57Bl/6 pups were euthanized by cervical dislocation prior to removal of the aortas. The vessels were cleaned, cut in 0.5 mm wide rings, and placed in a collagen growth matrix supplemented with CL. The results revealed a highly significant reduction of sprout growth (both length and quantity) at low, physiological concentrations. In conclusion, the results of this study demonstrate that CL significantly reduces microvessel formation and that it could potentially provide an interesting novel therapeutic target for angiogenesis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".