Comparison of CIDP and MGUS Associated Neuropathy Patients (P4.120)
Bibliographic record
Abstract
Objective: We aimed to determine whether the clinical characteristics, and response to treatment differed in monoclonal gammopathy of undetermined significance associated neuropathy (MGUSN), and chronic inflammatory demyelinating polyneuropathy (CIDP) patients. Background: There are varying reports on whether MGUSN patients are distinguishable from those with CIDP and whether specific MGUS subclasses are associated with specific clinical phenotypes. Design/Methods: We performed a retrospective chart review of MGUSN (n=56) and CIDP (n=67) patients. Data extracted included: demographics, neurological examination, and nerve conduction studies (NCS) at baseline and last visit. Clinical status was rated as: 0= worse, 1= unchanged, 2= stabilized after declining course, or 3= improved. The electrophysiology data were rated as: 0=worse, 1=stable or 2= improved. Statistical analyses were performed using JMP (version 9.0.2 for Macintosh, from SAS). Results: Seventy percent were male aged 68.1±12.6 years with neuropathy for 9.8±6.8 years and of follow up of 4.0±3.2 years. Neuropathy was more severe in CIDP (more weakness, abnormal reflexes and abnormal NCS parameters). CIDP patients were more likely to receive IVIG, prednisone, and azathioprine (p<0.0001) and were more likely to respond to IVIG (p<0.0001). The clinical neuropathy status remained unchanged in 52.8% of the MGUSN and 24.2% of the CIDP patients (p=0.0013), and stabilized in 7.6% of MGUSN and 30.3% of CIDP (p=0.0013). Forty six percent of MGUSN patients had IGM and did not differ from other immunoglobulin subclasses in response to treatment, although IGM patients had more severe neuropathy. Lambda light chains were observed more commonly in demyelinating MGUSN, while MAG positivity was exclusive to this subgroup of patients. Conclusion: The results suggest that MGUSN patients have less severe neuropathy, are treated less frequently, and respond less to treatment than CIDP patients. MGUSN patients may do well without treatment and exposure to potential adverse effects.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".