cDNA cloning, characterization and expression analysis of toll-like receptor 4 gene in goose
Bibliographic record
Abstract
Wang, F., Lu, L., Yuan, H., Tian, Y., Li, J., Shen, J., Tao, Z. and Fu, Y. 2011. cDNA cloning, characterization and expression analysis of toll-like receptor 4 gene in goose. Can. J. Anim. Sci. 91: 371–377. Toll-like receptor 4 (TLR4) plays an important role in activating proinflammatory pathways in response to various pathogens and fatty acids in mammals. In avian species, the TLR4 gene has been reported in chicken and zebra finch. We describe here the cloning and characterization of the TLR4 in goose. Goose TLR4 encodes an 843-amino-acid protein, which contains a signal peptide, extracelluar leucine-rich repeat domain, a transmembrane region and a toll-interleukin-1 receptor signaling domain. The deduced goose TLR4 protein shows more than 70% identity to chicken and zebra finch, but less than 50% identity to its mammalian counterparts. Quantitative real-time analysis reveals that the goose TLR4 mRNA is more expressed in abdominal fat and liver. We also identify the changes of goose TLR4 mRNA expression pattern after over-feeding treatment, which may reveal that the expression of goose TLR4 could respond to over-feeding treatment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".