The Comparative Double Blind Clinical Trial of Antihelmintic Efficacy Among Mebendazole, Thai Traditional Herbal Formulae and Areca catechu L.
Bibliographic record
Abstract
This study was carried out in Mahasarakham Primary Healthcare Centre, Mahasarakham province in the area of Northeastern of Thailand. The experiment was randomized control trial clinical comparative study in order to examine the antihelmintic activity efficacy among Mebendazole, Thai Traditional Formulae, Areca catechu Linn. in the treatment of 200 mixed worms infection in human. The experimental group consisted of 150 patients and 50 patients for control group with inclusion and exclusion criteria which were screened by the selected mix worm infected patients samples. The investigation and extraction of worm eggs per gram of patient feces method (EPG) were performed with Ether Formalin Sedimentation test. The percentage of reduction of eggs per gram (EPG) of patient feces were collected, counted and confirmed by parasitologist and the clinical efficacy were investigated by the physician and the pharmacist. The % EPG data were collected before and after the treatment with Mebendazole, Thai Traditional Formulae, Areca catechu Linn. and with placebo. The result showed that Thai Traditional Formulae had the highest efficacy in antihelmintic activity followed by the efficacy of Mebendazole and Areca catechu Linn. respectively. The antihelmintic efficacy which were measured by the % reduction of egg worm per gram of patient feces were 93.69, 87.50, 68.12 respectively. The statistical analysis confirmation in this study were carried out by Wilcoxson Signed Ranks test and Kruskal Wallis method. The suggestion of this study should increase the number of samples of worm infected patients which the samples can be identified with more specific helminthes genus and species in order to obtain various types of efficacy by the treatment of different medicine as mentioned above. Key words: Efficacy; Thai Traditional Formula medicine; Mebendazole; Areca Catechu Lin.; Egg per gram
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".