Nickel Homeostasis: Mechanism and function of<scp>NikR</scp>
Bibliographic record
Abstract
Abstract Nickel plays an important role in many organisms as a cofactor of enzyme active sites. However, nickel ions can be toxic and therefore require a robust regulation system. Found in a wide variety of bacteria and archaea,NikRis a transcription factor that regulates intracellular nickel homeostasis. The activities ofNikRhomologs from several microorganisms have been examined in detail both in vitro and in vivo. Ni2+loading promotesDNAbinding byNikR, an activity supplemented by additional, homolog‐specific cation requirements. Furthermore, there is evidence that the mechanism of nickel‐activatedDNAbinding includes stabilization of secondary structural elements of the protein that promote the formation of nonspecificDNAcontacts. Although a key function ofNikRis to regulate nickel uptake, the extent of its influence and its connection with other cellular pathways varies between organisms. Common features and contrasting activities withinNikRhomologs are presented and major outstanding questions are described.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".