Record W1901056508 · doi:10.1016/j.ygyno.2015.04.034

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

2015· review· en· W1901056508 on OpenAlexafffund

Antoinette Hollestelle, Frederieke H. van der Baan, Andrew Berchuck, Sharon E. Johnatty, Katja K.H. Aben, Bjarni A. Agnarsson, Kristiina Aittomäki, Elisa Alducci, Irene L. Andrulis, Hoda Anton‐Culver, Natalia Antonenkova, Antonis C. Antoniou, Carmel Apicella, Volker Arndt, Norbert Arnold, Banu Arun, Brita Arver, Alan Ashworth, Laura Baglietto, Rosemary L. Balleine, Elisa V. Bandera, Daniel Barrowdale, Yukie T. Bean, Lars Beckmann, Matthias W. Beckmann, Javier Benı́tez, Andreas Berger, Raanan Berger, Benoit Beuselinck, Maria Bisogna, Line Bjørge, Carl Blomqvist, Natalia Bogdanova, Anders Bojesen, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Louise A. Brinton, Angela Brooks‐Wilson, Fiona Bruinsma, Joan Brunet, Thomas Brüning, Agnieszka Budziłowska, Clareann H. Bunker, Barbara Burwinkel, Ralf Bützow, Saundra S. Buys, Maria A. Caligo, Ian Campbell, Jonathan Carter, Jenny Chang‐Claude, Stephen J. Chanock, Kathleen Claes, J. Margriet Collée, Linda S. Cook, Fergus J. Couch, Angela Cox, Daniel W. Cramer, Simon S. Cross, Julie M. Cunningham, Cezary Cybulski, Kamila Czene, Francesca Damiola, Agnieszka Dansonka‐Mieszkowska, Hatef Darabi, Miguel de la Hoya, Anna DeFazio, Joseph Dennis, Peter Devilee, Ed Dicks, Orland Dı́ez, Jennifer A. Doherty, Susan M. Domchek, Cecilia M. Dorfling, Thilo Dörk, Isabel dos‐Santos‐Silva, Andreas du Bois, Martine Dumont, Alison M. Dunning, M. Durán, Douglas F. Easton, Diana Eccles, Robert P. Edwards, Hans Ehrencrona, Bent Ejlertsen, Arif B. Ekici, Steve D. Ellis, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Lídia Feliubadaló, Jonine D. Figueroa, Dieter Flesch‐Janys, Olivia Fletcher, Annette Campbell Fontaine, Stefano Fortuzzi, Florentia Fostira, Brooke L. Fridley, Tara M. Friebel, Eitan Friedman, Grace Friel, Debra Frost, Judy E. Garber, Montserrat García‐Closas, Simon A. Gayther, Aleksandra Gentry‐Maharaj, Anne‐Marie Gerdes, Graham G. Giles, Rosalind Glasspool, Gord Glendon, Andrew K. Godwin, Marc T. Goodman, Martin Gore, Mark H. Greene, Mervi Grip, Jacek Gronwald, Daphne Gschwantler Kaulich, Pascal Guénel, Starr R Guzman, Lothar Haeberle, Christopher A. Haiman, Per Hall, Sandra L. Halverson, Ute Hamann, Thomas van Overeem Hansen, Philipp Harter, Jaana M. Hartikainen, Sue Healey, Alexander Hein, Florian Heitz, Brian E. Henderson, Josef Herzog, Michelle A.T. Hildebrandt, Claus Høgdall, Estrid Høgdall, Frans B.L. Hogervorst, John L. Hopper, Keith Humphreys, Tomasz Huzarski, Evgeny N. Imyanitov, Claudine Isaacs, Anna Jakubowska, Ramūnas Janavičius, Katarzyna Jaworska, Allan Jensen, Uffe Birk Jensen, Nichola Johnson, Arja Jukkola‐Vuorinen, Maria Kabisch, Beth Y. Karlan, Vesa Kataja, Noah D. Kauff, Linda E. Kelemen, Michael J. Kerin, Lambertus A. Kiemeney, Susanne K. Kjær, Julia A. Knight, Jacoba P Knol-Bout, Irene Konstantopoulou, Veli‐Matti Kosma, Camilla Krakstad, Vessela N. Kristensen, Karoline Kuchenbaecker, Jolanta Kupryjańczyk, Yael Laitman, Diether Lambrechts, Sandrina Lambrechts, Melissa C. Larson, Adriana Lasa, Pierre Laurent‐Puig, Conxi Lázaro, Nhu D. Le, Loı̈c Le Marchand, Arto Leminen, Jenny Lester, Douglas A. Levine, Jingmei Li, Dong Liang, Annika Lindblom, Noralane M. Lindor, Jolanta Lissowska, Jirong Long, Karen H. Lu, Jan Lubiński, Lene Lundvall, Galina Lurie, Sara Margolin, Frédérique Mariette, Frederik Marmé, John W.M. Martens, Leon F.A.G. Massuger, Christine Maugard, Sylvie Mazoyer, Lesley McGuffog, Valerie McGuire, Catriona McLean, Iain A. McNeish, Alfons Meindl, F. Ménégaux, Primitiva Menéndez, Janusz Menkiszak, Usha Menon, Arjen R. Mensenkamp, Nicola Miller, Roger L. Milne, Francesmary Modugno, Marco Montagna, Kirsten B. Moysich, Heiko Müller, Anna Marie Mulligan, Taru Muranen, Steven A. Narod, Katherine L. Nathanson, Roberta B. Ness, Heli Nevanlinna, Patrick Neven, Finn Cilius Nielsen, Sune F. Nielsen, Børge G. Nordestgaard, Robert L. Nussbaum, Kunle Odunsi, Kenneth Offit, Edith Oláh, Olufunmilayo I. Olopade, Janet E. Olson, Sara H. Olson, Jan C. Oosterwijk, Irene Orlow, Nick Orr, Sandra Oršulić, Ana Osório, Laura Ottini, James Paul, Celeste Leigh Pearce, Inge Søkilde Pedersen, Bernard Peissel, Tanja Pejović, Liisa M. Pelttari, Jo Perkins, Jenny Permuth‐Wey, Paolo Peterlongo, Julian Peto, Catherine M. Phelan, Kelly‐Anne Phillips, Marion Piedmonte, Malcolm C. Pike, Radka Platte, Joanna Plisiecka-Hałasa, Elizabeth M. Poole, Bruce Poppe, Katri Pylkäs, Paolo Radice, Susan J. Ramus, Timothy R. Rebbeck, Malcolm Reed, Gad Rennert, Harvey A. Risch, Mark E. Robson, Gustavo C. Rodriguez, Atocha Romero, Mary Anne Rossing, Joseph H. Rothstein, Anja Rudolph, Ingo B. Runnebaum, Ritu Salani, Helga B. Salvesen, Elinor J. Sawyer, Joellen M. Schildkraut, Marjanka K. Schmidt, Rita K. Schmutzler, Andreas Schneeweiß, Minouk J. Schoemaker, Michael Schrauder, Fredrick R. Schumacher, Ira Schwaab, Giulietta Scuvera, Thomas A. Sellers, Gianluca Severi, Caroline Seynaeve, Mitul Shah, Martha J. Shrubsole, Nadeem Siddiqui, Weiva Sieh, Jacques Simard, Christian F. Singer, Olga M. Sinilnikova, Dominiek Smeets, Christof Sohn, Maria Soller, Honglin Song, Penny Soucy, Melissa C. Southey, Christa Stegmaier, Dominique Stoppa‐Lyonnet, Lara Sucheston, Anthony J. Swerdlow, Ingvild L. Tangen, Muy‐Kheng Tea, Manuel R. Teixeira, Kathryn L. Terry, Mary Beth Terry, Mads Thomassen, Pamela J. Thompson, Laima Tihomirova, Marc Tischkowitz, Amanda E. Toland, Rob A.�E.�M. Tollenaar, Ian Tomlinson, Diana Torres, Thérèse Truong, Helen Tsimiklis, Nadine Tung, Shelley S. Tworoger, Jonathan P. Tyrer, Celine M. Vachon, Laura van ‘t Veer, Anne M. van Altena, Christina Jacomina van Asperen, David Van Den Berg, Ans M.W. van den Ouweland, Helena C. van Doorn, Els Van Nieuwenhuysen, Elizabeth J. van Rensburg, Ignace Vergote, Senno Verhoef, Robert A. Vierkant, Joseph Vijai, Allison F. Vitonis, Anna von Wachenfeldt, Christine Walsh, Qin Wang, Shan Wang‐Gohrke, Barbara Wappenschmidt, Maren Weischer, Jeffrey N. Weitzel, Caroline Weltens, Nicolas Wentzensen, Alice S. Whittemore, Lynne R. Wilkens, Robert Winqvist, Anna H. Wu, Xifeng Wu, Hannah Yang, Daniela Zaffaroni, M. Pilar Zamora, Wei Zheng, Argyrios Ziogas, Georgia Chenevix‐Trench, Paul D.P. Pharoah, Matti A. Rookus, Maartje J. Hooning, Ellen L. Goode

Bibliographic record

VenueGynecologic Oncology · 2015

Typereview

Languageen

FieldBiochemistry, Genetics and Molecular Biology

TopicMicroRNA in disease regulation

Canadian institutionsMcGill UniversityUniversity of TorontoUniversity Health NetworkWomen's College HospitalAlberta Health ServicesBC Cancer AgencyCentre hospitalier universitaire de QuébecLunenfeld-Tanenbaum Research Institute

FundersNiilo Helanderin SäätiöMedical Research and Materiel CommandNational Cancer InstituteEuropean Regional Development FundSeventh Framework ProgrammeInstituto de Salud Carlos IIICancer Council Western AustraliaCancer Council NSWCancer Council VictoriaCancer Center, University of KansasNational Institutes of HealthCentre Léon BérardInstitut Català de la SalutLiepaja City CouncilGesellschaft der Freunde der Medizinischen Hochschule HannoverUniversität UlmInstitut Gustave-RoussyMinistero dello Sviluppo EconomicoAgence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du TravailFederal Agency for Science and InnovationUppsala UniversitetClalit Health ServicesInstitute of Cancer ResearchHospices Civils de LyonLegal Services CorporationSyöpäjärjestötRadboud Universitair Medisch CentrumNational Health and Medical Research CouncilDeutsche KrebshilfeRoyal Marsden NHS Foundation TrustSahlgrenska UniversitetssjukhusetOulun YliopistoNational Institute for Health and Care ResearchJewish General HospitalCanadian Institutes of Health ResearchEuropean CommissionLietuvos Mokslo TarybaKuopion Yliopistollinen SairaalaIstituto Toscano TumoriRoswell Park Cancer InstituteIsrael Cancer AssociationLinköpings UniversitetSigrid Juséliuksen SäätiöUnicancerGeneral Secretariat for Research and TechnologyNorges ForskningsrådLunds UniversitetNederlandse Organisatie voor Wetenschappelijk OnderzoekCalifornia Breast Cancer Research ProgramMcGill UniversityGeneralitat de CatalunyaCancer Council South AustraliaIstituto Oncologico VenetoMemorial Sloan-Kettering Cancer CenterInstitut National Du CancerCancer Council QueenslandOak FoundationLeids Universitair Medisch CentrumFundacja na rzecz Nauki PolskiejBreakthrough Breast CancerFundación Científica Asociación Española Contra el CáncerVrije Universiteit AmsterdamOhio State UniversityCanadian Breast Cancer Research AllianceUniversiteit LeidenCelma Mastry Ovarian Cancer FoundationMinistero della SaluteInstitut National de la Santé et de la Recherche MédicaleCancerfondenWellcomeFriedrich-Alexander-Universität Erlangen-NürnbergRobert Bosch StiftungHungarian Scientific Research FundCancer Association of South AfricaCancer Institute NSWWellcome TrustAgence Nationale de la RechercheAmerican Cancer SocietyRadboud UniversiteitCancer AustraliaState Education Development Agency Republic of LatviaHelsingin ja Uudenmaan SairaanhoitopiiriDepartment of Defence, Australian GovernmentAcademy of FinlandKing's College LondonCancer Research UKVlaamse regeringFundación Mutua MadrileñaHamburger KrebsgesellschaftCenter for Molecular Medicine Cologne, University of CologneLon V. Smith FoundationRutgers Cancer Institute of New JerseyMinistère du Développement Économique, de l’Innovation et de l’ExportationBundesministerium für Bildung und ForschungFrancis Crick InstituteGénome QuébecCancer Care OntarioDeutsches KrebsforschungszentrumFred C. and Katherine B. Andersen FoundationUmeå UniversitetHelsingin YliopistoLjósmæðrafélag ÍslandsLigue Contre le CancerKansas Bioscience AuthorityCancer Council TasmaniaItä-Suomen YliopistoFox Chase Cancer CenterKWF KankerbestrijdingAgency for Science, Technology and ResearchUniversity of ChicagoU.S. Department of Health and Human ServicesCreighton UniversityMinisterstwo Edukacji i NaukiNordic Cancer UnionBreast Cancer Research FoundationNational Breast Cancer FoundationEuropean Social FundMedical Research CouncilMayo Foundation for Medical Education and ResearchUniversity of MelbourneCalifornia Department of Public HealthKræftens BekæmpelseNational Institute on Handicapped ResearchSusan G. Komen for the CureAssociazione Italiana per la Ricerca sul CancroRoswell Park Alliance Foundation, Roswell Park Cancer InstituteFondation de FranceUniversitair Medisch Centrum GroningenMinnesota Ovarian Cancer AllianceSusan G. KomenMinisterio de Economía y CompetitividadErasmus Medisch CentrumBeth Israel Deaconess Medical CenterFonds Wetenschappelijk OnderzoekU.S. ArmyLandspítali HáskólasjúkrahúsOvarian Cancer Research Fund

KeywordsMedicineOvarian cancerOncologyKRASInternal medicineBreast cancerGynecologyCancerColorectal cancer

DOI10.1016/j.ygyno.2015.04.034

Abstract

fetched live from OpenAlex

No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002

metaresearch head score (Gemma)0.002

Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated

Candidate categoriesMeta-epidemiology (narrow), Research integrity, Insufficient payload (model declined to judge)

Consensus categoriesnone

DomainCandidate signal: none · Consensus signal: none

Study designCandidate signal: Not applicable · Consensus signal: none

GenreCandidate signal: Review · Consensus signal: Review

Teacher disagreement score0.940

Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

Category	Codex	Gemma
Metaresearch	0.002	0.002
Meta-epidemiology (narrow)	0.001	0.000
Meta-epidemiology (broad)	0.003	0.001
Bibliometrics	0.000	0.000
Science and technology studies	0.000	0.000
Scholarly communication	0.000	0.000
Open science	0.001	0.000
Research integrity	0.002	0.000
Insufficient payload (model declined to judge)	0.001	0.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.113

GPT teacher head0.445

Teacher spread0.332 · how far apart the two teachers sit on this one work

Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it