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Record W1906517363 · doi:10.1002/ijc.29559

Alcohol consumption and the risk of renal cancers in the <scp>E</scp>uropean prospective investigation into cancer and nutrition (EPIC)

2015· article· en· W1906517363 on OpenAlex
Magdalena B. Wozniak, Paul Brennan, Darren R. Brenner, Kim Overvad, Anja Olsen, Anne Tjønneland, Marie‐Christine Boutron‐Ruault, Françoise Clavel‐Chapelon, Guy Fagherazzi, Verena Katzke, Tilman Kühn, Heiner Boeing, Manuela M. Bergmann, Annika Steffen, Androniki Naska, Antonia Trichopoulou, Dimitrios Trichopoulos, Calogero Saieva, Sara Grioni, Salvatore Panico, ­Rosario ­Tumino, Paolo Vineis, H. Bas Bueno‐de‐Mesquita, Petra H. Peeters, Anette Hjartåker, Elisabete Weiderpass, Larraitz Arriola, Esther Molina‐Montes, Eric J. Duell, Carmen Santiuste, Ramón Alonso de la Torre, Aurelio Barricarte Gurrea, Tanja Stocks, Mattias Johansson, Börje Ljungberg, Kay‐Tee Khaw, Ruth C. Travis, Amanda J. Cross, Neil Murphy, Elio Ríboli, Ghislaine Scélo

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueInternational Journal of Cancer · 2015
Typearticle
Languageen
FieldMedicine
TopicCancer Risks and Factors
Canadian institutionsAlberta Health Services
FundersNational Cancer InstituteInstituto de Salud Carlos IIIMedical Research CouncilNorges ForskningsrådInstitut Gustave-RoussyLigue Contre le CancerDeutsches KrebsforschungszentrumAssociazione Iblea per la Ricerca EpidemiologicaDeutsche KrebshilfeNordForskHellenic Health FoundationStavros Niarchos FoundationCancerfondenInstitut National de la Santé et de la Recherche MédicaleWorld Health OrganizationCancer Research UKBundesministerium für Bildung und ForschungNational Institute for Health and Care ResearchCompagnia di San PaoloEuropean CommissionUniversitetet i TromsøCentre International de Recherche sur le CancerAssociazione Italiana per la Ricerca sul CancroEcumenical Project for International Cooperation
KeywordsEuropean Prospective Investigation into Cancer and NutritionEPICAlcohol consumptionProspective cohort studyMedicineCancerConsumption (sociology)Environmental healthInternal medicineOncologyAlcoholPhysiologyBiologyBiochemistry

Abstract

fetched live from OpenAlex

Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 through to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment versus the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), 0.91 (0.63-1.30), respectively, (ptrend = 0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.015
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.034
GPT teacher head0.339
Teacher spread0.306 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it