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Record W1908864745 · doi:10.1016/j.cell.2015.09.033

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

2015· article· en· W1908864745 on OpenAlexaff
Giovanni Ciriello, Michael L. Gatza, Andrew H. Beck, Matthew D. Wilkerson, Suhn K. Rhie, Alessandro Pastore, Hailei Zhang, Michael D. McLellan, Christina Yau, Cyriac Kandoth, Reanne Bowlby, Hui Shen, Sikander Hayat, Robert J. Fieldhouse, Susan C. Lester, Gary M. Tse, Rachel E. Factor, Laura C. Collins, Kimberly H. Allison, Yunn-Yi Chen, Kristin C. Jensen, Nicole B. Johnson, Steffi Oesterreich, Gordon B. Mills, Andrew D. Cherniack, Gordon Robertson, Christopher C. Benz, Chris Sander, Peter W. Laird, Katherine A. Hoadley, Tari A. King, Charles M. Perou, Rehan Akbani, J. Todd Auman, Miruna Balasundaram, Saianand Balu, Thomas Barr, Andrew H. Beck, Stephen C. Benz, Mario Berríos, Rameen Beroukhim, Tom Bodenheimer, Lori Boice, Jay Bowen, Denise Brooks, Lynda Chin, Juok Cho, Sudha Chudamani, Tanja M. Davidsen, John A. Demchok, Jennifer B. Dennison, Li Ding, Ina Felau, Martin L. Ferguson, Scott Frazer, Stacey Gabriel, Jianjiong Gao, Julie M. Gastier-Foster, Nils Gehlenborg, Mark Gerken, Gad Getz, William J. Gibson, D. Neil Hayes, David I. Heiman, Andrea Holbrook, Robert A. Holt, Alan P. Hoyle, Hai Hu, Mei Huang, Carolyn M. Hutter, E. Shelley Hwang, Steven J.M. Jones, Zhenlin Ju, Jaegil Kim, Phillip H. Lai, Michael S. Lawrence, Kristen M. Leraas, Tara M. Lichtenberg, Pei Lin, Shiyun Ling, Jia Liu, Wenbin Liu, Laxmi Lolla, Yiling Lu, Yussanne Ma, Dennis T. Maglinte, Elaine R. Mardis, Jeffrey R. Marks, Marco A. Marra, Cynthia McAllister, Shaowu Meng, Matthew Meyerson, Richard A. Moore, Lisle E. Mose, Andrew J. Mungall, Bradley A. Murray, Rashi Naresh, Michael S. Noble, Olufunmilayo Olopade, Peter J. Park, Todd Pihl, Gordon Saksena, Steven E. Schumacher, Kenna Shaw, Nilsa C. Ramirez, W. Kimryn Rathmell, Jeffrey Roach, A. Gordon Robertson, Jacqueline E. Schein, Nikolaus Schultz, Margi Sheth, Yan Shi, Juliann Shih, Carl Simon Shelley, Craig D. Shriver, Janae V. Simons, Heidi J. Sofia, Matthew G. Soloway, Carrie Sougnez, Charlie Sun, Roy Tarnuzzer, Daniel Guimarães Tiezzi, David Van Den Berg, Doug Voet, Yunhu Wan, John N. Weinstein, Daniel J. Weisenberger, Richard K. Wilson, Lisa Wise, Maciej Wiznerowicz, Junyuan Wu, Ye Wu, Liming Yang, Travis Zack, Jean C. Zenklusen, Jiashan Zhang, Erik Zmuda

Bibliographic record

VenueCell · 2015
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCancer Genomics and Diagnostics
Canadian institutionsCanada's Michael Smith Genome Sciences CentreUniversity of British ColumbiaBC Cancer Agency
FundersU.S. National Library of MedicineNational Institute of General Medical SciencesNational Cancer Institute
KeywordsBiologyInvasive lobular carcinomaFOXA1PTENCancer researchBreast cancerGATA3PI3K/AKT/mTOR pathwayCancerInvasive ductal carcinomaGeneticsGeneTranscription factorSignal transduction

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.238
Teacher spread0.225 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1,960
Published2015
Admission routes1
Has abstractno

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