Effect of inhalation exposure to an occupational allergen on sputum levels of brain-derived neurotrophic factor
Bibliographic record
Abstract
Background: There is raising interest on the potential role of neurotrophins in pathogenic mechanisms and clinical manifestations of respiratory allergic diseases. The neurotrophin brain-derived neurotrophic factor (BDNF) seems to play a role in the pathophysiology of asthma. However, there are not data on changes in sputum levels of BDNF after inhalation challenge with occupational allergens. Thus, we sought to assess the effect of inhalation challenge with a high-molecular-weight agent on levels of BDNF in induced sputum in patients with allergic occupational asthma. Methods: Eight patients sensitized to flour underwent control and active challenge on consecutive days. Bronchial response to challenge was monitored by measuring FEV1 before the challenge and then serially for 7 h afterwards. Induced sputum was performed at the end of control and active challenge days. Results: In contrast to control day, flour challenge induced clinically significant bronchial reactions in all subjects. After flour challenge, the levels of BDNF in induced sputum were significantly increased as compared to levels after control challenge (p=0.02). Also, a nonsignificant increase in the number of eosinophils as compared to control challenge levels (p=0.07) was observed. No correlation between BDNF levels and inflammatory cells in induce sputum was noted. Conclusions: We showed that BDNF increases in induced sputum after inhalation challenge with flour. The results support the suggestion that neurotrophins may be involved in the pathogenesis of allergic occupational asthma.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".