Effect of Chronic Pretreatment with the Sigma Ligand JO 1784 on CRF-lnduced Changes in Behaviour, Neurotransmitter and Immunological Function in the Rat
Bibliographic record
Abstract
The effects of the chronic administration of the sigma ligand JO 1784 (igmesine) CRF-induced changes in some behavioural, immune, endocrine and neurotransmitter parameters were studied. In the elevated plus maze, CRF (1.0 microgram i.c.v. daily x 5 days) induced a reduction in the number of entries and time spent on the open arms was significantly attenuated by the sigma ligand JO 1784 (3 mg/kg x 21 days) treatment. In the open field apparatus, the CRF-induced increase in the locomotor activity was also reduced by JO 1784 administration. JO 1784 treatment did not alter the concentration of the biogenic amine transmitters in the hypothalamus, nor reverse the increase in the turnover of serotonin and dopamine caused by CRF. JO 1784 treatment also failed to reverse a CRF-induced increase in the serum corticosterone, but it did reverse the reduction in phytohaemagglutinin and concanavalin A-induced lymphocyte proliferation caused by CRF but not the changes in the lymphocyte and neutrophil numbers caused by the peptide. These results demonstrate that JO 1784 has some antistress properties in CRF-treated rats.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".