Thermally Stable Multilamellar Structure of DNA/Cationic Lipid Complex in the Bulk State
Bibliographic record
Abstract
The effect of temperature on the two types of multilamellar structures, LI and LII, formed by the complexes of DNA with a cationic lipid, cholesteryl 3β-N-(dimethylamionethyl) carbamate (DC-Chol), in the bulk state has been investigated by small angle X-ray scattering (SAXS). LI phase composing of A-DNA intercalated between the lipid bilayers with tilted tails was formed at lower lipid-to-base pair molar ratio (x < 2), while LII phase consisting of B-DNA bound to untilted lipid was formed at x > 2. In addition to the differences in lipid packing state and DNA conformation, these two lamellar phases also displayed different thermal stability. LI phase was highly thermally stable as its interlamellar distance remained essentially unperturbed even after the denaturation of A-DNA in the complex at elevated temperature. By contrast, the interlamellar distance of LII phase decreased with increasing temperature due to the release of bound water and B-DNA denaturation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".