Influence of the adipose derived hormone resistin on signal transducer and activator of transcription factors, steroidogenesis and proliferation of Leydig cells
Bibliographic record
Abstract
To explore whether resistin, an adipose derived hormone linked to insulin resistance, influence steroidogenic genes expressions and Leydig cells function or not. Various Leydig cell lines were exposed to increasing doses of resistin with or without cAMP. Changes were monitored at the protein level for signal transducer and activator of transcription (STAT) factors and steroidogenic components, steroidogenic acute regulatory protein (STAR) and cholesterol side-chain cleavage enzyme (CYP11A1), for progesterone production and cell viability. Resistin had no effect on progesterone production, despite an increase in nuclear translocation of STAT1, STAT3 and STAT5 and unexpected synergy with cAMP in the synthesis of STAR and CYP11A1. In addition, exposure to normal levels of resistin (10 ng/mL) seemed to have beneficial effects on Leydig cell function, as it increased cells viability and proliferation. Our results suggest that resistin may function as an endocrine mediator linking metabolism and male reproduction.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".