Modulation of Structural Protein Content of the Myotendinous Junction Following Eccentric Contractions
Bibliographic record
Abstract
The objective of this study was to test the hypothesis that vinculin and talin, two cytoskeletal proteins of the myotendinous junction (MTJ), would be up-regulated following damaging eccentric contractions. Mouse plantar flexor muscles were submitted in situ to three 5 min periods of eccentric contractions. Talin and vinculin content, in vitro contractile properties and MTJ histology were examined at 0, 3, 7, 14, and 28 days post-exercise. The eccentric protocol led to significant decreases in maximum tetanic tension at 0, 3, and 7 days post-protocol. Histological examination did confirm that tissue damage was present at the MTJ where talin and vinculin are highly concentrated. In the type I soleus muscle talin content increased slightly at 7 days post-eccentric protocol compared to SHAM. In the type II plantaris muscle eccentric contraction led to an increase for vinculin and talin contents that was 2-3 fold higher than in the soleus; these significant changes were still present 28 days postexercise. These results show that eccentric contractions can trigger intense protein synthesis activity at the MTJ most likely related to myofibrillogenesis associated with MTJ remodeling.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".