BLAME CANADA: GROWING QUESTIONS ABOUT BUDESONIDE
Bibliographic record
Abstract
Controlled ileal release budesonide in pediatric Crohn's disease: efficacy and effect on growth. Kundahl P, Zachos M, Holmes JL, Griffiths AM. J Ped Gastro Nutr 2001;33:75–80. The investigators performed a retrospective chart review on 32 children ages 6–19 years with Crohn's disease (CD) of the ileum and cecum treated with controlled ileal release (CIR) budesonide. Concomitant medications included aminosalicylates in seven patients, ciprofloxacin in 6 patients, metronidazole in seven patients, and azathioprine in two patients. The initial dose used was 9 mg/day, given for approximately 2 months. On this dose, 19 patients (59%) were improved, and 8 patients (25%) were felt to be in complete remission. Of the 19 patients judged to be responders after 2 months, 12 were maintained on 6 mg/day of budesonide. Of these 12, 6 patients (5 males) were prepubertal and were followed for linear growth. After 1 year of chronic budesonide treatment, growth in these six children was noted to be suboptimal (2 cm/year) (normal is 4 cm/year or greater). The authors concluded that daily budesonide used as maintenance therapy may result in impaired linear growth in children. However, they could not determine whether the reduced linear growth seen was a direct side effect of the budesonide, or occurred because the CD in these children was inadequately controlled.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.026 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.021 | 0.011 |
| Scholarly communication | 0.008 | 0.005 |
| Open science | 0.003 | 0.003 |
| Research integrity | 0.102 | 0.066 |
| Insufficient payload (model declined to judge) | 0.014 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".