Current Status of the Nutritional Guidance of Baby to Human T-Cell Leukemia/Lymphoma Virus Type I Carriers by Japanese Obstetricians
Bibliographic record
Abstract
In humans, breast-feeding is the major route for mother-tochild transmission of human T-cell leukemia/lymphoma virus type I (HTLV-I). HTLV-I transmission by breast milk is associated with ingestion of infected cells and can be prevented by formula-feeding [1]. Therefore, in most of the developed world, mothers with a proven HTLV-I infection should be advised not to breast-feed their babies. In our recent observation in Japan, the number of HTLV-1 carrier in Japanese pregnant women has been estimated to be 1,620 (0.16% of all pregnant women) per year [2]. Based on the guidelines for obstetrical practice in Japan, the HTLV-1 carrier should be recommended to be instructed in the following methods as alternatives to breast-feeding for the prevention of HTLV-1 vertical transmission: 1) formula feeding, 2) frozen-thawed breast milk and 3) short-term breast-feeding within the first 3 months after birth [3]. However, the current status of the nutritional guidance of baby to HTLV-1 carriers by Japanese obstetricians has not been well examined. To examine the current status of mother-to-child transmission of HTLV-I preventing in Japan, on December 2014, we requested 2,544 obstetricians that are members of Japan Association of Obstetricians and Gynecologists (JAOG) and directors of each obstetric facility to provide information of the strategies. Of the 2,544 obstetricians, 1,345 (52.9%) responded. In cases of pregnant woman with positive western blot (WB) test, 953 (70.9%) of the Japanese obstetricians perform the informed choice of the three methods described above, 337 (25.1%) recommend formula feeding, and six (0.4%) recommend long-term breast milk, respectively. In Japan, because the mother-to-child transmission rates under the above three methods have been reported to be both about 3% [4, 5], about 70% of Japanese obstetricians perform the informed choice of the three methods as alternatives to breast-feeding. Breastfeeding is beneficial to the health of both the infant and mother, and mothers generally believe this. Therefore, it is possible that many of the HTLV-I-carrier mothers want to choose breastfeeding as the method of feeding their infants. However, the ground studies for the transmission rates with frozen-thawed breast milk and short-term breast-feeding have not been large (n = 64 and 162 in cases of frozen-thawed breast milk and short-term breast-feeding, respectively) [4]. Therefore, we have not yet evaluated the utility of these methods precisely. It is necessary to clarify the issues by follow-up of all cases prospectively. On the other hand, it has been described that the diagnosis of HTLV-1 carriers in their children is possible at the age of ≥ 3. However, only 698 obstetricians (55.4%) of them recommend the HTLV-1 screening tests for the children of women with positive WB test when they become ≥ 3 years old. The HTLV-1 screening tests might fraught with problems of announcements and personal information; however, the results are possible to facilitate the future diagnosis of adult T-cell leukemia and HTLV-1 associated myelopathy. Therefore, it seems to be necessary to convey to the mothers about the diagnostic methods of the HTLV-1 carriers of their children. These problems will be expected to be elucidated by a nationwide prospective cohort study.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".