The Effect of Deactivating Groups in the Formation of Some Biologically Important Lactams (Isatins) and their Further Derivatization
Bibliographic record
Abstract
Treatment of different aromatic primary amines (7a-b) with chloral hydrate andhydroxylamine hydrochloride under microwave (MW) conditions afforded correspondingisonitrosoacetanilides (6a-b). These intermediate compounds (6a-b) were cyclized inconc. H2SO4 medium to give cyclic amides (5a-b) by means of elcetrophilicaromatic substitution reaction. The microwave (MW) mediated treatment of compound5a with thiosemicarbazide afforded the corresponding Schiff-base 4a, which undergoescyclization to give thiadiazoline (1). Beside, compound 4a was also treated with aq KOHsolution under MW condition to give triazinothione (3). The Sn-HCl mediatedreduction of compound 3 afforded the corresponding 6-aminothione (2). On the otherhand, compound 5b was treated with o-phenylenediamine under MW condition to givethe corresponding quinoxaline derivative 4b in excellent yield. DOI: http://dx.doi.org/10.3329/jbcs.v25i1.11771 Journal of Bangladesh Chemical Society, Vol. 25(1), 46-52, 2012
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".