Electrochemical Investigations of M-DNA Self-Assembled Monolayers on Gold Electrodes
Bibliographic record
Abstract
Monolayers of double-stranded DNA on polycrystalline gold electrodes were prepared by chemisorbing SS-5‘-GTCACGATGGCCCAGTAGTT-3‘ ( 1 ) hybridized with its complementary strand 5‘-AACTACTGGGCCATCGTGAC-3‘ ( 2 ) onto gold through a disulfide linkage, giving a monolayer with hydroxylalkyl chains adjacent to the double-stranded DNA (ds-DNA). The system forms a stable and well-behaved ds-DNA monolayer on gold, which reduces the signal transduction between a solution electrophore and the gold surface. Upon addition of Zn 2+ to the solution at pH 8.6, Zn 2+ associates with the ds-DNA and form M-DNA. In contrast to ds-DNA, the signal transduction is significantly enhanced. The heterogeneous electron-transfer rate ( k ET ) between the ferricyanide electrophore and the surface was determined for bare gold, ds-DNA, and M-DNA monolayers. k ET for electron transfer from the solution electrophore to the gold surface through the M-DNA monolayer is 1.2 × 10 -4 ± 0.2 × 10 -4 cm s -1, which is smaller than for bare gold under the same conditions ( k ET = 9.1 × 10 -4 ± 0.2 × 10 -4 cm s -1 ). For simple ds-DNA, k ET was too slow to be measured.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".