Netrin-1 Receptor Deficient Mice: A Phenotype Resistant to Psychopathology?
Bibliographic record
Abstract
Dysfunctions of the midbrain dopaminergic system are implicated in the psychopathology of schizophrenia and other disorders including drug addiction. Abnormalities in brain development play an etiological role in schizophrenia leading to altered dopaminergic function in adulthood and increased vulnerability to the effects of stimulant drugs. Netrins are proteins that organize neuronal connectivity during development and their receptors are highly expressed in dopaminergic neurons. We find that adult netrin-1 receptor deficient mice exhibit altered dopamine-related behaviors and show profound molecular and anatomical changes in dopamine systems that appear opposite to those observed in developmental animal models of schizophrenia or following chronic use of drugs of abuse. Significantly, the signs of this apparently ‘protective’ phenotype are not evident in pre-pubertal mice. We propose that variations in netrin-1 receptor function at critical periods in development could contribute to individual differences in susceptibility to psychopathology.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".