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Coincident Acetylcholine Receptor Antibody and Anti-Asialo GM1 Antibody in a Young Male

2003· article· en· W1967773387 on OpenAlexaff
Cory Toth, Chris White

Bibliographic record

VenueJournal of Clinical Neuromuscular Disease · 2003
Typearticle
Languageen
FieldMedicine
TopicMyasthenia Gravis and Thymoma
Canadian institutionsHeritage Medical Research ClinicUniversity of Calgary
FundersMedical Research Council
KeywordsMedicineMyasthenia gravisWeaknessDenervationMuscle biopsyPrednisoneAcetylcholine receptorAntibodyNeuromuscular junctionAutoantibodyPyridostigminePlasmapheresisMuscle weaknessAcetylcholineInternal medicineBiopsyImmunologyReceptorNeuroscienceSurgeryBiology

Abstract

fetched live from OpenAlex

Coexistence of myasthenia gravis with an immunologically mediated neuropathy syndrome is rare. We present a young male patient with a history of generalized muscle weakness and fatigue with electrophysiological evidence of both a motor neuron syndrome and a neuromuscular junction abnormality accompanied by pathologic evidence of denervation with muscle biopsy. Laboratory evidence for both acetylcholine receptor (AchR) antibodies and anti-asialo GM1 antibodies, both of high levels, was found. The patient's fatigue and weakness showed an objective response to pyridostigmine, prednisone, and immunoglobulin therapy over a period of 9 months.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.004
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.010
Threshold uncertainty score0.747

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.028
GPT teacher head0.386
Teacher spread0.358 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2003
Admission routes1
Has abstractyes

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