Effect of gamma irradiation on blood from glucose 6 phosphate dehydrogenase deficient blood donors
Why this work is in the frame
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Bibliographic record
Abstract
Recently, the irradiation of cellular blood components has received increased attention. Normal red blood cells (RBC) when subjected to gamma irradiation show increase in haemolysis and increased storage lesions. Glucose 6 phosphate dehydrogenase (G6PD) deficient blood is lacking in anti-oxidant properties which protect the RBC membrane and therefore when subjected to gamma irradiation, it may lead to increased haemolysis. In this study, 500 healthy non-remunerated blood donors were screened for G6PD deficiency. About 350 ml of whole blood was collected from 10 G6PD deficient donors (cases) and 10 units were collected from donors who were not deficient for G6PD (controls). All units were subjected to gamma irradiation of 25 Gy by a self contained gamma cell irradiator (Nordion Canada) on day 0 and then stored at 4 degrees C. Sampling was done from these cases and controls on day 0, 7, 14 and 21. Estimation of free plasma hemoglobin (Hb), free plasma potassium (K) and lactate dehydrogenase (LDH) was performed. It was found that there were no significant changes between the cases and controls in any of the parameters assessed, although the values for all the parameters were higher in case group at the end of storage period, these differences were not statistically significant.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it