178 IS PROGESTERONE THE DETERMINING REGULATORY FACTOR BEHIND OVULATION RATE IN EWES?
Bibliographic record
Abstract
Ovarian antral follicles in the ewe grow in an orderly succession, producing 3–4 waves per oestrous cycle. In prolific sheep, some large antral follicles from the second-last wave of the oestrous cycle are added to the ovulatory follicles emerging just before oestrus to give a higher ovulation rate; it is feasible that regression of these follicles is prevented by an increase in serum concentrations of FSH and/or LH pulsatility at pro-oestrus. Prolific sheep tend to have a shorter luteal phase than non-prolific breeds and there is a great deal of evidence that luteal progesterone (P4), in addition to regulating LH release, may govern the secretion of FSH heralding the emergence of follicular waves. The specific purpose of the present experiments was to determine whether or not extending the duration of the luteal phase would alter the ovulation rate in prolific sheep. In both studies, exogenous P4 (7.5 mg ewe–1 IM) was administered on Days 11 and 12 (Day 0 = ovulation) in moderately prolific Rideau Arcott x Polled Dorset (Exp. 1, n = 8) and highly prolific Olkuska ewes (Exp. 2, n = 7), while the equinumerous groups of animals served as controls (CTR). Transrectal ovarian ultrasonography was performed daily and jugular blood samples were drawn twice a day from Day 9 until ovulation. All single-time point observations were compared between groups by Student t-test. Progesterone injections resulted in uniform increments in serum P4 levels in all animals allocated to the treatment (TRT) groups. However, the mean duration of the interovulatory interval did not differ (P > 0.05) between TRT and CTR groups of ewes in both experiments. The mean (± s.e.m.) ovulation rate was 1.6 ± 0.2 v. 3.2 ± 0.4 (Exp. 1; P < 0.001) and 3.2 ± 0.8 v. 4.0 ± 1.0 (Exp. 2; P < 0.05) in TRT v. CTR ewes, respectively. There were no differences in terms of the timing of penultimate and final wave emergence between the two subsets of animals studied in either experiment. The number/percentage of ovulating follicles from the penultimate wave of the interovulatory interval studied was 0.25 ± 0.16 v. 1.75 ± 0.45 (P < 0.01)/25.0 ± 16.4% v. 75.0 ± 16.4% (P < 0.05) in Exp. 1 and 0.50 ± 0.30 v. 1.60 ± 0.40 (P < 0.05)/13.8 ± 9.0% v. 53.4 ± 16.7% (P < 0.05) in Exp. 2, in TRT v. CTR animals, respectively. In summary, administration of P4 at the end of diestrus reduced the incidence of ovulations from the penultimate wave of the oestrous cycle in moderately and highly prolific strains of sheep. Therefore, progesterone appears to be a key endocrine signal governing the ovulation rate in cyclic sheep, presumably by acting directly at the level of the ovary. The present results may pave a way to devising a simple and inexpensive method of controlling lamb productivity in commercial flocks of sheep and fertility in other polyovulatory species.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".