MétaCan
Menu
Back to cohort

Mesenchymal chondrosarcoma of the thyroid – a rare tumour at an unusual site

2004· article· en· W1968205368 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueApmis · 2004
Typearticle
Languageen
FieldMedicine
TopicBone Tumor Diagnosis and Treatments
Canadian institutionsSt. Thomas Hospital
Fundersnot available
KeywordsPathologyDifferential diagnosisThyroidChondrosarcomaCD99CD117Mesenchymal chondrosarcomaMesenchymal stem cellImmunohistochemistryMedicineLesionStromaHemangiopericytomaSolitary fibrous tumorBiologyCD34Internal medicineStem cellVimentin

Abstract

fetched live from OpenAlex

We describe the light microscopic, immunohistochemical and ultrastructural features of the first case in the literature of a primary mesenchymal chondrosarcoma (MC) of the thyroid and discuss its differential diagnosis at unusual extraskeletal sites. A nodular lesion of the thyroid with no evidence of extrathyroid disease showed the bimorphic pattern and haemangiopericytoma-like areas typical of MC. In the undifferentiated areas, the cells were CD99 positive/CD117 negative, while the stroma showed focal positivity for alpha-inhibin. In spite of its rarity, it is important to diagnose primary mesenchymal chondrosarcoma in a parenchymatous organ such as the thyroid because its biological behaviour may be different from that of tumours of similar morphology and complete resection is the treatment of choice. The patient is free of disease nearly 66 months after its first presentation. Cytogenetic and immunohistological markers may play important roles in diagnosis of this lesion in future, especially with limited tissue samplings; however, for the present a thorough sampling of the tumour remains the best diagnostic strategy.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.044
Threshold uncertainty score0.314

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.256
Teacher spread0.244 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it