Paraoxonase 1, 2 and 3 DNA variants and susceptibility to childhood inflammatory bowel disease
Bibliographic record
Abstract
MSI tumours and also think that we should spare no efforts in trying to understand the molecular basis of the response to chemotherapy in that kind of tumour.The importance of DNA methylation in prognosis and chemotherapy response is not completely known, and, in our opinion, research in that area is scarce and inconclusive.In our own and other published studies, most of the tumours that show a lack of efficacy of 5-FU in MMR-deficient tumours are sporadic (and therefore with MSI caused by hypermethylation of the promoter region of MLH1), suggesting that the lack of efficacy of adjuvant 5-FU on MSI tumours could happen in both hereditary and sporadic MSI tumours.Further studies on the role of hypermethylation in prognosis and chemotherapy response in colorectal cancer are under way in our series.Soon, we will be able to report the 5-year follow-up analysis in these series, which will bring forth new and interesting data on this topic.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.006 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.007 | 0.003 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".