Synthesis and thiol‐responsive degradation of polylactide‐based block copolymers having disulfide junctions using ATRP and ROP
Bibliographic record
Abstract
A new method to synthesize a variety of well‐controlled polylactide (PLA)‐based block copolymers having disulfide linkages at block junctions (PLA‐ss‐PATRPs) was investigated. The method uses a combination of ring‐opening polymerization (ROP) and atom transfer radical polymerization (ATRP) that initiates the synthesis of a new disulfide‐labeled double‐head initiator having both terminal OH and Br groups (HO‐ss‐iBuBr). The amount of tin catalyst and polymerization time significantly influenced the control of ROP initiated with HO‐ss‐iBuBr. A series of ATRP of various methacrylates as well as acrylate and styrene in the presence of the resulting PLA‐ss‐iBuBr macroinitiators proceeded in a living manner. These well‐controlled PLA‐ss‐PATRPs were further characterized for thermal properties using differential scanning calorimetry and thiol‐responsive degradation upon the cleavage of disulfide linkages. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym. Chem. 2013, 51, 3071–3080
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".