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Record W1969164710 · doi:10.1136/bmj.c1373

Commentary: Ethics in conduct of trials in developing countries

2010· letter· en· W1969164710 on OpenAlexaff
Charles Weijer

Bibliographic record

VenueBMJ · 2010
Typeletter
Languageen
FieldImmunology and Microbiology
TopicImmune responses and vaccinations
Canadian institutionsWestern University
Fundersnot available
KeywordsDeveloping countryEngineering ethicsComputer scienceData scienceMedicineEconomic growthEconomicsEngineering

Abstract

fetched live from OpenAlex

The paper by Roth and colleagues1 on a randomised controlled trial of BCG revaccination in Guinea-Bissau highlights the importance of conducting vaccine trials in developing countries as well as the ethical difficulties faced by investigators in these settings. Guinea-Bissau has an infant mortality rate of 117 per 1000 live births, the fifth highest rate in the world.2 The best hope for substantial improvements in child health comes from public health interventions, including effective vaccine programmes. Vaccine efficacy might be lower in developing countries because of poverty and malnutrition. Once the efficacy of a vaccine is established, however, it is commonly assumed that it will confer a proportional survival benefit. The results of the BCG revaccination trial show that non-vaccine factors might undermine this assumption, and the authors conclude correctly that trials should examine the impact …

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesResearch integrity
Consensus categoriesResearch integrity
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.009
Threshold uncertainty score0.998

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0050.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0030.005
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.126
GPT teacher head0.397
Teacher spread0.271 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2010
Admission routes1
Has abstractyes

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