Antidiabetic Activity of<i>Nigella sativa</i>. Seed Extract in Cultured Pancreatic β-cells, Skeletal Muscle Cells, and Adipocytes
Why this work is in the frame
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Bibliographic record
Abstract
The seeds of Nigella sativa L. (NS), a plant of the Runanculaceae family, are used in traditional medicine in North Africa and the Middle East for the treatment of diabetes.Despite widespread use and a number of scientific studies, the target tissues and cellular mechanisms of action of this plant product are not well understood.This study evaluated the effects of NS seed crude ethanol extract on insulin secretion in INS832/13 and TC-tet lines of pancreatic -cells and on glucose disposal by C2C12 skeletal muscle cells and 3T3-L1 adipocytes.An 18-h treatment with NS amplified glucose-stimulated insulin secretion by more than 35% without affecting sensitivity to glucose.NS treatment also accelerated -cell proliferation.An 18-h treatment with NS increased basal glucose uptake by 55% (equivalent to approximately two-fold the effect of 100 nM insulin) in muscle cells and approximately by 400% (equal to the effect of 100 nM insulin) in adipocytes; this effect was perfectly additive to that of insulin in adipocytes.Finally, NS treatment of pre-adipocytes undergoing differentiation accelerated triglyceride accumulation comparably with treatment with 10 M rosiglitazone.It is concluded that the well-documented in vivo antihyperglycemic effects of NS seed extract are attributable to a combination of therapeutically relevant insulinotropic and insulin-like properties.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it