Some assembly required: SOCE and Orai1 channels couple to NFAT transcriptional activity via calmodulin and calcineurin
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Advances in our ability to monitor the temporal and spatial dynamics of intracellular second messengers such as Ca(2+) and cyclic nucleotides at millisecond and sub-micron levels of resolution have greatly increased our understanding of cellular signal transduction mechanisms. Thus, it is now well appreciated that second messengers can rise and fall within discrete regions of the intracellular compartment, as opposed to global changes, and on a time scale determined by the local collection of signaling molecules responsible for the synthesis and degradation/re-uptake of the second messenger. Efforts to identify the components of such macromolecular signaling domains have revealed the presence of hormone receptors, modifying enzymes and scaffolding proteins that tend to assemble and organize these complexes. Emerging evidence now suggests that these signal transduction entities need not be pre-existing, static complexes within the cell, but in fact, may dynamically assemble in response to a specific stimulus. Such an arrangement would thus allow key signaling molecules to be trafficked where they are needed, thereby allowing a cell to utilize these resources more effectively. On the flip side, having such molecules constantly remain within a single cellular domain would facilitate rapid signaling responses and help maintain fidelity of the pathway.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it