Distinct function of Th1 and Th2 type delayed type hypersensitivity: Protective and pathological reactions to chlamydial infection
Bibliographic record
Abstract
The role of delayed-type hypersensitivity (DTH) to chlamydial infection has been shown to be a double-edged sword to the host. Reported animal and human studies have, on the one hand, shown that DTH is associated with protective immunity against chlamydial infection and, on the other hand, shown links to immunopathology. Using a murine lung infection model, we recently demonstrated that there might be two different functional types of DTH induced by chlamydial infection based on its association with cytokine patterns. Th1 type DTH is associated with protection while Th2 type DTH is associated with immunopathology. The Th2 type DTH demonstrated in IFNgamma gene knockout (KO) mice is characterized by eosinophil infiltration in addition to mononuclear cell infiltration that exists in Th1 DTH, observed in wild-type C57BL/6 mice and IL-10 KO mice. In addition, the inflammatory cells in IFNgamma KO mice fail to target the cellular sites of chlamydial inclusions in infected tissues and fail to clear the infection. The functional differences in Th1 and Th2 type DTH responses may account for the dual role DTH plays in chlamydial protective immunity and immunopathology.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".