P2.11 ASSESSING VENTRICULAR-VASCULAR INTERACTIONS IN GIRLS WITH TURNER SYNDROME: A PILOT STUDY
Bibliographic record
Abstract
Objectives: Women with Turner Syndrome (TS) have increased incidence of cardiovascular disease, thought to be related to a clustering of risk factors including insulin resistance, hypertension, obesity and dyslipidemia. The aim of this study was to non-invasively determine and compare ventricular and vascular function in girls with TS to healthy controls. Methods: Ventricular assessment included standard echocardiographic M-mode and 2-D volumetric techniques, plus Doppler tissue velocities. Vascular assessment included applanation tonometry, carotid ultrasound, echo-Doppler of the aorta and brachial artery reactivity. Between groups comparisons were performed using parametric methods with p-values>0.05 considered significant. Results: Seventeen girls with TS without significant congenital heart disease and 17 healthy age-matched girls (8–18 years) were studied. Heights and weights were similar, but BMI increased in TS, suggesting increased weight-for-height, as expected. Resting heart rates and peripheral and derived central systolic and diastolic blood pressures were increased in TS. Carotid distensibility was decreased in TS, but derived augmentation index, carotid-femoral pulse wave velocity, aortic dimensions and echo-Doppler measures of aortic stiffness and vascular impedance, and flow-mediated dilation assessment of endothelial function, were all similar. Left ventricular systolic function by M-mode and two-dimensional volumetric assessment and myocardial performance index by Doppler were similar, but increased E/E’ ratios suggestive of increased ventricular filling pressures were found in TS. Conclusions: Elevated resting heart rates and blood pressures, decreased carotid distensibility and suggestion of increased ventricular filling pressures in girls with TS, may be playing a role in future increased risk of cardiovascular disease and warrant further investigation.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".