Botryoidal Assembly of Cholesteryl−Pullulan/Poly(<i>N</i>-isopropylacrylamide) Nanogels
Bibliographic record
Abstract
Hybrid nanogels consisting of cholesteryl-modified pullulan (CHP) and poly(N-isopropylacrylamide) (PNIPAM) were synthesized by graft free-radical copolymerization of N-isopropylacrylamide (NIPAM) onto methacryloyl-substituted CHP nanogels (CHPMA) in water at 50 degrees C in the presence of a water-soluble free radical initiator. Depending on the initial NIPAM/CHPMA ratio, CHP-PNIPAM (CN) nanogels containing 30.8-84.8 wt % PNIPAM were obtained in the form of self-assembled nanoparticles with a hydrodynamic radius (Rh) of 69.0-116.0 nm in water kept at 20 degrees C. Hybrid nanogels of sufficiently high NIPAM content, such as the sample CN90, which contains 79.6 wt % NIPAM, exhibited a two-step response to changes in solution (3 mg/mL) temperature: a decrease in Rh from 93 to 57 nm as the temperature increased from 20 to 35 degrees C, followed by a sharp increase in Rh from 57 nm to 90 nm at 55 degrees C. Both steps in this temperature response were reversible. The multistep response to temperature of the CN nanogels was attributed to the morphology of the nanogels, which are seen as consisting of grape-like (botryoidal) clusters of associated native nanogels held together via cholesteryl cross-linking points and held together by the grafted PNIPAM chains.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".