Seafood consumption and persistent organic pollutants as triggers of autoimmunity among Gullah African Americans
Bibliographic record
Abstract
Local seafood is a dietary staple among the African American Gullah population of South Carolina. High levels of persistent organic pollutants (POPs) have been found in local bottlenose dolphins, sentinel species for human health and consumers of many of the same fish as the Gullah. Links have been established between these bioaccumulating, ubiquitous compounds and deleterious health effects in humans. The objective was to determine whether levels of POPs, specifically perfluorinated compounds (PFCs), correlate with fish intake and markers of immune dysfunction in genetically at-risk individuals. At the onset of the Persistent Organic Pollutants in AutoImmunity (POPAI) study, one-on-one interviews were conducted with Gullah community members to validate a comprehensive environmental exposure questionnaire. The validated questionnaire, including a seafood intake survey, was then administered prospectively to patients with lupus, first-degree relatives of lupus patients, and unrelated nonlupus controls participating in the SLE in Gullah Health (SLEIGH) study. PFC levels (PFOS, PFOA and PFNA), antinuclear antibody titers and other autoantibodies were measured in the serum of participants drawn at the time of their study visit. Seafood intake questionnaires received from 103 Gullah participants enrolled in the SLEIGH study found 57% consumed locally caught seafood at least once a month and 40% consumed species known to contain high levels of POPs in the Charleston Harbor area. Preliminary results from 33 Gullah controls show that all have measurable serum levels of PFCs (specifically PFOS, PFOA and PFNA) from baseline and follow-up visits 7.3 ± 1.4 years apart, with annual servings of seafood directly correlating with serum PFOS and PFNA (p=0.02 and 0.03). ANA positive controls (48% at baseline) had higher mean levels compared to ANA negative controls for PFOS (75.1 vs 48.2 ng/ml, p=0.06), PFOA (7.0 vs 5.8, p=NS) and PFNA (3.2 vs 2.1, p=0.04). These ongoing studies address concerns of the Sea Island Gullah community regarding the potential immune health effects of the bioaccumulating pollutants found in local dietary staples such as fish.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.008 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".