Vascular consequences of a high-fat meal in physically active and inactive adults
Bibliographic record
Abstract
Habitually active adults (ACT) typically exhibit lower postprandial lipemia, a condition that may attenuate oxidative stress and endothelial dysfunction following a high-fat meal (HFM), compared with inactive adults (INA). Our objective was to compare triglycerides (TAG), superoxide dismutase activity (SOD), oxidative stress (thiobarbituric reactive substances; TBARS), and brachial artery flow-mediated dilation (FMD%) before and after an HFM challenge in ACT and INA. ACT (n = 7) and INA (n = 7) subjects were matched for body mass index, age, and sex. Plasma TAG, SOD, TBARS, and FMD% were measured at baseline and 4 h after an HFM challenge. TAG significantly increased following the HFM in INA (4.15 ± 3.79 mmol·L(-1) vs. 8.07 ± 5.12 mmol·L(-1)) and in ACT (2.16 ± 0.55 mmol·L(-1) vs. 3.24 ± 1.40 mmol·L(-1)). Baseline TBARS were greater in ACT and remained unchanged in response to the HFM in both INA (5.1 ± 2.7 mmol·L(-1) vs. 6.9 ± 2.9 mmol·L(-1)) and ACT (8.6 ± 2.0 mmol·L(-1) vs. 7.9 ± 1.9 mmol·L(-1)). ACT exhibited greater SOD than INA at baseline (8.6 ± 0.7 U·mL(-1) vs. 7.8 ± 0.6 U·mL(-1)) and following the HFM (9.3 ± 1.2 U·mL(-1) vs. 8.0 ± 0.7 U·mL(-1)). Postprandial FMD% was decreased in INA (9.1% ± 4.0% vs. 6.2% ± 3.4%), yet remained unchanged in ACT (7.9% ± 3.7% vs. 9.3% ± 3.2%). In conclusion, the differential responses following an HFM support the concept that habitual physical activity can attenuate the negative postprandial alterations that affect vascular health.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".