Effect of Subinhibitory Concentrations of Ciprofloxacin and Gentamicin on the Adherence of Pseudomonas aeruginosa to Vero Cells and Voided Uroepithelial Cells
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The effect of subinhibitory concentrations (1/8 x, 1/16 x, 1/32 x MIC) of ciprofloxacin or gentamicin on the adherence of Pseudomonas aeruginosa to Vero cells and voided uroepithelial cells was studied using two different assay methods. Strains studied included both reference strains and clinical strains, including mucoid and nonmucoid isolates. Sub-MICs of ciprofloxacin decreased adherence to Vero cells and voided uroepithelial cells in 3 of 4 ciprofloxacin-susceptible nonmucoid isolates but not in ciprofloxacin-resistant or mucoid isolates. Sub-MICs of gentamicin significantly reduced adherence in 5 of 7 nonmucoid strains but not in mucoid strains. Gentamicin effect on adherence did not correlate with susceptibility to ciprofloxacin. We conclude that ciprofloxacin susceptibility determines the effect of sub-MICs of ciprofloxacin on P. aeruginosa adherence to Vero cells and voided uroepithelial cells. In addition, both the Vero cell assay and voided uroepithelial cell assay demonstrated similar results.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it