Effect of Subinhibitory Concentrations of Ciprofloxacin and Gentamicin on the Adherence of Pseudomonas aeruginosa to Vero Cells and Voided Uroepithelial Cells
Bibliographic record
Abstract
The effect of subinhibitory concentrations (1/8 x, 1/16 x, 1/32 x MIC) of ciprofloxacin or gentamicin on the adherence of Pseudomonas aeruginosa to Vero cells and voided uroepithelial cells was studied using two different assay methods. Strains studied included both reference strains and clinical strains, including mucoid and nonmucoid isolates. Sub-MICs of ciprofloxacin decreased adherence to Vero cells and voided uroepithelial cells in 3 of 4 ciprofloxacin-susceptible nonmucoid isolates but not in ciprofloxacin-resistant or mucoid isolates. Sub-MICs of gentamicin significantly reduced adherence in 5 of 7 nonmucoid strains but not in mucoid strains. Gentamicin effect on adherence did not correlate with susceptibility to ciprofloxacin. We conclude that ciprofloxacin susceptibility determines the effect of sub-MICs of ciprofloxacin on P. aeruginosa adherence to Vero cells and voided uroepithelial cells. In addition, both the Vero cell assay and voided uroepithelial cell assay demonstrated similar results.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".