Emerging aspects of ER organization in root hair tip growth: Lessons from RHD3 and atlastin
Bibliographic record
Abstract
Cell polarity is a fundamental aspect of eukaryotic cells. A central question for cell biologists is how the polarity of a cell is established and maintained. Root hairs are exceptionally polarized structures formed from specific root epidermal cells. The morphogenesis of root hairs is characterized by the localized cell growth in a small dome at the tip of the hair, a process called tip growth. Root hairs are thus an attractive model system to study the establishment and maintenance of cell polarity in eukaryotes. Research on Arabidopsis root hairs has identified a plethora of molecular and cellular components that are important for root hair tip growth. Recently, studies on RHD3 and Atlastin have revealed a surprising similarity with respect to the role of the tubular ER network in tip growth of root hairs in plants and the axonal outgrowth of corticospinal neurons in neurological disorders known as hereditary spastic paraplegia (HSP). In this mini-review, we highlight recent progress in understanding of the function and regulation of RHD3 in the generation of the tubular ER network and discussed ways in which RHD3 could be involved in the establishment and maintenance of root hair tip growth.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".