Protein Resistance of Surfaces Prepared by Chemisorption of Monothiolated Poly(ethylene glycol) to Gold and Dendronization with Aliphatic Polyester Dendrons: Effect of Hydrophilic Dendrons
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Protein adsorption to surfaces prepared by chemisorption of thiol-terminated poly(ethylene glycol) (HS-PEG 650 -OH) to gold-coated silicon wafers followed by functionalization of the terminal PEG OH groups with aliphatic polyester dendrons was investigated. Chemisorption of HS-PEG 650 -OH to the gold surfaces was carried out under cloud-point conditions to give a chain density of ∼3.7 chains/nm 2, as calculated from AFM film thickness measurements. Dendronization of the PEG-functionalized surfaces with aliphatic polyester dendrons, generations 1−4, was achieved using divergent dendron growth. The hydrophilicity of the surfaces increased significantly with increasing dendron generation as shown by water contact angle data. The effect of the hydrophilic dendrons on protein adsorption from phosphate-buffered saline (PBS) and plasma are reported. Adsorption of both 125 I-radiolabled fibrinogen and lysozyme onto the dendronized surfaces showed that protein adsorption increases upon introduction of dendrons to the PEG-functionalized surfaces. The similarity between fibrinogen and lysozyme adsorption suggests that resistance of the dendronized surfaces to proteins follows the same trend regardless of protein size.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it