P3.03 BIOACTIVES OF WILD BERRIES: POTENTIAL ALTERNATIVES TO VASODILATOR DRUGS
Bibliographic record
Abstract
Objective: One of the major indicators of intact endothelial function is basal nitric oxide (NO) activity.Further, is seems to be likely that statin therapy exerts beneficial effects on vascular function, at least in part via an improvement of NO bioavailability.Design and Methods: In a double-blind crossover study twenty-nine hypercholesterolemic patients were randomly assigned to receive rosuvastatin and placebo for 42 days.Pulse wave analysis was assessed after 30 minutes of rest (baseline) and after infusion of L-NMMA.The magnitude of the increase in central augmentation index (cAIx) in response to inhibition of NO synthase (NOS) by L-NMMA is indicative of basal NO activity.Results: CAIx was significantly lower (18.3AE10versus 21.9AE12%, pZ0.027) with rosuvastatin compared to placebo.There was no increment of cAIx in response to L-NMMA in placebo group.In contrast, cAIx increased significantly in response to L-NMMA (20.5AE11 versus 25.7AE10mmHg, pZ0.001) in rosuvastatin group.The percentage of increase of cAIx tended to be more pronounced after treatment with rosuvastatin compared to placebo (53.7AE92 versus 14.1AE36%, pZ0.087), indicating increased basal NOS activity with rosuvastatin treatment.Pulse pressure amplification (PPA) improved (1.31AE0.2versus 1.26AE0.2%, pZ0.016) after rosuvastatin compared to placebo.Regression analyses revealed that both LDL-cholesterol and CRP-levels are independent determinants of basal NO activity improvement, which itself is an independent determinant of vascular function, expressed by an improvement of arterial wave reflection and PPA.Conclusion: Rosuvastatin improves vascular function by restoring endothelial function expressed by improved NO production in patients with hypercholesterolemia, thereby exerting anti-atherosclerotic effects on the vascular wall.P3.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".