The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins
Bibliographic record
Abstract
A highly conserved family of putative tumor suppressor genes Although the pathogenesis of HME was first described nearly 200 years ago (1), it is only in the past few years that elegant genetic analyses have determined that both hereditary and sporadic cases of exostoses are linked to two main loci, EXT1 on chromosome 8q24.1 (4) and EXT2 on chromosome 11p11-p12 (5), with rare linkage to another locus, EXT3, on chromosome 19p (6).Because exostosis formation is associated with loss of heterozygosity at one or several EXT loci, it has been suggested that the EXT proteins have tumor suppres-The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".