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Record W1977691283 · doi:10.1159/000124825

Presence of an Atrial Natriuretic Factor-Like Peptide in the Rat Superior Cervical Ganglia

2008· article· en· W1977691283 on OpenAlexafffund
Waldemar Debinski, Jolanta Gutkowska, Otto Kuchel, Kàroly Rácz, Nguyen T. Buu, Marc Cantin, Jacques Genest

Bibliographic record

VenueNeuroendocrinology · 2008
Typearticle
Languageen
FieldMedicine
TopicHeart Failure Treatment and Management
Canadian institutionsUniversité de MontréalMontreal Clinical Research Institute
FundersHypertension CanadaMedical Research Council Canada
KeywordsInternal medicineEndocrinologyCervical gangliaRadioimmunoassaySuperior cervical ganglionNeuropeptideAtrial natriuretic peptideReceptorNeurotransmitterIn vitroPeptide hormoneAldosteronePeptideBiologySympathetic nervous systemChemistryMedicineBiochemistry

Abstract

fetched live from OpenAlex

The presence of a peptide resembling atrial natriuretic factor (ANF) was demonstrated in the peripheral sympathetic ganglia of the rat by a sensitive radioimmunoassay. Partially purified ANF-like compounds from the superior cervical ganglia exhibited biological activities which were similar to the synthetic peptide of cardiac origin; they inhibited ACTH-stimulated aldosterone release in vitro and displaced labelled [125I]-ANF from rat adrenocortical cell receptors. The exact source and role of ANF in peripheral nervous structures is not fully understood. We suggest that in sympathetic ganglia ANF may act as a neurotransmitter and/or neuromodulator in a manner similar to other neuropeptides.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.285
Teacher spread0.252 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations29
Published2008
Admission routes2
Has abstractyes

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