Effects of delaying the LH surge and altering LH secretion on plasma hormones and embryo production in heifers superstimulated with FSH
Bibliographic record
Abstract
Ovarian follicles were ablated by ultrasound-guided transvaginal aspiration in 20 Holstein heifers allocated to four groups (n = 5 per group). The first group (SOV) was superstimulated conventionally with FSH. In the other superstimulated groups, the LH surge was delayed by 24 h with progesterone (CIDR) and 100-μg injection of GnRH. The second group (CIDR-3.5d) received the CIDR on the second day of superstimulation. To increase LH pulsatility, the third group (CIDR-3.5d-GnRH-Pulsed) received repeated 5-μg injections of GnRH during superstimulation and the fourth group (CIDR-7d), received the CIDR with a first prostaglandin, 2 d prior to superstimulation. The number of corpora lutea (CL) and embryos was not significantly different (P > 0.1) in CIDR-3.5d compared to SOV (9.4 ± 2.0 vs. 13.8 ± 2.0 CL and 3.6 ± 1.2 vs. 5.8 ± 1.2 embryos, respectively). In the CIDR-3.5d-GnRH-Pulsed group, the 100-μg injection of GnRH failed to induce an LH surge and there were no CLs and no embryos recovered. In the CIDR-7d group, the number of CLs (5.6 ± 2.0, P < 0.05) and embryos (1.8 ± 1.2, P < 0.01) were reduced compared to SOV. In conclusion, a 24-h delay of the LH surge with a CIDR did not improve embryo production. In this delayed-surge model, increasing LH pulsatility prior to or during superstimulation resulted in a decrease in ovulation rate and embryo production. Key words: Superstimulation (FSH), GnRH, LH, CIDR, progesterone, oestradiol, embryo
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".