Effects of etanercept therapy on fatigue and symptoms of depression in subjects treated for moderate to severe plaque psoriasis for up to 96 weeks
Bibliographic record
Abstract
Conflicts of interest: see Acknowledgments. Trial registration: This study is registered with ClinicalTrials.gov with the identifier NCT00111449. Sir, Fatigue and depression have been associated with psoriasis.1, 2 Proinflammatory cytokines such as tumour necrosis factor (TNF), implicated in the pathogenesis of psoriasis, also have been linked to symptoms of fatigue3 and depression.4 Etanercept is a soluble TNF receptor‐Fc fusion protein that has U.S. Food and Drug Administration approval for the treatment of moderate to severe plaque psoriasis. Results have been reported previously of a 12‐week, randomized, double‐blind trial of etanercept or placebo in psoriasis.5 Herein, we report the longer‐term results from this study. After week 12, 591 subjects (95% of enrolled subjects) entered a second portion of the study in which all received open‐label etanercept 50 mg twice weekly. Of these, 233 subjects (77%) from the etanercept/etanercept group and 231 subjects (81%) from the placebo/etanercept group completed 84 weeks of open‐label etanercept.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".