Effects of etanercept therapy on fatigue and symptoms of depression in subjects treated for moderate to severe plaque psoriasis for up to 96 weeks
Bibliographic record
Abstract
Conflicts of interest: see Acknowledgments. Trial registration: This study is registered with ClinicalTrials.gov with the identifier NCT00111449. Sir, Fatigue and depression have been associated with psoriasis.1, 2 Proinflammatory cytokines such as tumour necrosis factor (TNF), implicated in the pathogenesis of psoriasis, also have been linked to symptoms of fatigue3 and depression.4 Etanercept is a soluble TNF receptor‐Fc fusion protein that has U.S. Food and Drug Administration approval for the treatment of moderate to severe plaque psoriasis. Results have been reported previously of a 12‐week, randomized, double‐blind trial of etanercept or placebo in psoriasis.5 Herein, we report the longer‐term results from this study. After week 12, 591 subjects (95% of enrolled subjects) entered a second portion of the study in which all received open‐label etanercept 50 mg twice weekly. Of these, 233 subjects (77%) from the etanercept/etanercept group and 231 subjects (81%) from the placebo/etanercept group completed 84 weeks of open‐label etanercept.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".