Syntheses of the phosphodiesterase‐4 inhibitors [<sup>11</sup>C]Ro 20‐1724, R‐, R/S‐ and S‐[<sup>11</sup>C]rolipram
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract The high affinity and selective cAMP‐specific phosphodiesterase‐4 inhibitors Ro 20‐1724, R ‐, R/S ‐ and S ‐rolipram were labeled with 11 C by O ‐[ 11 C]methylation of their respective phenolic precursors using [ 11 C]methyl iodide. The desmethyl precursor of Ro 20‐1724 was prepared by selective dealkylation with iodotrimethylsilane, whereas, dealkylation of racemic rolipram was not selective and yielded several products. Enantiomeric separation of R ‐ and S ‐desmethylrolipram was carried out by chiral semi‐preparative high performance liquid chromatography. The final 11 C‐labeled products were prepared in high radiochemical purity (>99%), yields (45‐75%, decay‐corrected) and specific activities [18.5‐92.5 GBq/µmol], within 30 min from end‐of‐bombardment. Copyright © 2001 John Wiley & Sons, Ltd.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it