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Comparison of Post Hoc Multiple Pairwise Testing Procedures as Applied to Small k-Group Logrank Tests

2013· article· en· W1981620646 on OpenAlexvenueno aff
Moonseong Heo, Andrew C. Leon

Bibliographic record

VenueInternational Journal of Statistics in Medical Research · 2013
Typearticle
Languageen
FieldMathematics
TopicAdvanced Causal Inference Techniques
Canadian institutionsnot available
FundersNational Institute of Mental Health
KeywordsBonferroni correctionMultiple comparisons problemPairwise comparisonPost-hoc analysisPost hocFalse discovery rateStatisticsType I and type II errorsLog-rank testStatistical hypothesis testingMathematicsCensoring (clinical trials)Computer scienceMedicineSurvival analysisInternal medicineBiology

Abstract

fetched live from OpenAlex

The logrank test is widely used to compare groups on distribution of survival time in the presence of censoring. There is no convention for post hoc pairwise comparisons after a significant omnibus k-group logrank test. This simulation study compares four post hoc pairwise testing procedures: Bonferroni, Dunn-Šidák, Hochberg, and unadjusted post hoc logrank test procedure. Evaluation criteria include, familywise type I error rate, correct decision rate, number of correctly rejected pairs, and false discovery rate. We demonstrated that when conditioned upon rejection of the omnibus test, multiplicity adjustments may be unnecessary and can be overly conservative when k is at most 4, or number of comparisons is no greater than 6. This is supported by the results that the performance of the unadjusted post hoc logrank test procedure is preferred over the others on all criteria except for the false discovery rate. The Hochberg procedure appears to be superior among the adjustments examined. Data from a clinical trial for suicide prevention illustrate these approaches where number of comparison groups is often limited.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.142
metaresearch head score (Gemma)0.458
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.858
Threshold uncertainty score0.751

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1420.458
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.003
Bibliometrics0.0030.003
Science and technology studies0.0020.004
Scholarly communication0.0020.004
Open science0.0030.003
Research integrity0.0020.004
Insufficient payload (model declined to judge)0.0080.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.302
GPT teacher head0.553
Teacher spread0.251 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designSimulation or modeling
DomainMethods
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2013
Admission routes1
Has abstractyes

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