T-box genes organize the dorsal ventral leg axis in<i>Drosophila melanogaster</i>
Why this work is in the frame
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Bibliographic record
Abstract
A key event in fly limb development is the binary subdivision of the cardinal axes of imaginal discs by selector genes.(1-3) As an example, all limbs are partitioned into anterior and posterior compartments through the expression of engrailed (en) in posterior cells of imaginal discs and en expression is both necessary and sufficient to direct posterior instead of default anterior development.(4-8) In the leg imaginal disc, posterior en-expressing cells secrete the ligand Hedgehog (Hh), which in turn activates ventral Wingless (Wg) expression and dorsal Decapentaplegic (Dpp) expression in domains that bisect the imaginal disc.(9,10) Dpp and Wg act in concert to specify distal fates by inducing the expression of downstream genes including the selector gene Distal-less,(11,12) which is both necessary and sufficient for the development of the distal part of the leg.(13) In contrast, the dorsal (D) versus ventral (V) decision is mediated by antagonistic signaling between Dpp and Wg, with Dpp specifying D and Wg specifying V.(10,14-22) Recently, we have shown that the ventral specific T-box transcription factors midline(mid) and H15 are downstream effectors of Wg acting as selector genes that specify ventral fate.(23).
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it