Photic input pathways that mediate the <i>Drosophila</i> larval response to light and circadian rhythmicity are developmentally related but functionally distinct
Bibliographic record
Abstract
The Drosophila melanogaster larval photosensory organ that mediates the response to light consists of bilaterally symmetrical clusters of 12 photoreceptors. These are distinguished on the basis of expression of the rhodopsins Rh5 and Rh6. The Rh6-expressing cells correspond to the Hofbauer-Buchner (H-B) eyelet found later in the posterior margin of the adult compound eye and recently shown to function as an input pathway in the entrainment of circadian rhythmicity in adult Drosophila. In addition, the axons of the larval photoreceptors are found in intimate association with a subset of the main circadian pacemaker neurons located in the developing accessory medulla, the small ventral lateral neurons (LNv). The observed spatial overlap between components of the circadian circuitry, input pathway, and pacemaker neurons-and the larval visual organ-suggest a functional relationship between these two photosensory input pathways. In this study we determined the requirement of specific rhodopsin-expressing photoreceptors including the presumptive H-B eyelet and pacemaker neurons in the larval locomotory response to visual stimuli. Our results demonstrate that two of the most important components of the neuronal circuitry underlying circadian rhythmicity in Drosophila, namely, the extraretinal H-B cluster and the circadian pacemakers, while in intimate association with the larval visual system are not required for the larval motor response to light.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".