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Record W1982749466 · doi:10.4212/cjhp.v65i5.1175

Management of Chronic Obstructive Pulmonary Disease in Patients Admitted to a Tertiary Care Centre for Exacerbation of Their Disease

2012· article· en· W1982749466 on OpenAlexaffvenueabout
Roxanne Dault, Anne-Isabelle Dubé, Lucie Blais, Robert Boileau, Pierre Larrivée, Mario-Eddy Dumas, Marie-France Beauchesne

Bibliographic record

VenueThe Canadian Journal of Hospital Pharmacy · 2012
Typearticle
Languageen
FieldMedicine
TopicChronic Obstructive Pulmonary Disease (COPD) Research
Canadian institutionsCentre Hospitalier Universitaire de SherbrookeHôpital du Sacré-Cœur de MontréalUniversité de MontréalUniversité de Sherbrooke
Fundersnot available
KeywordsExacerbationTertiary carePulmonary diseaseMedicineDiseaseIntensive care medicineEmergency medicineInternal medicine

Abstract

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Background: Acute exacerbation of chronic obstructive pulmonary disease (COPD) is associated with an accelerated decline in lung function and a significant decrease in health status. Maintenance therapy with respiratory medications can reduce the risk of such exacerbations.Objective: To determine whether respiratory maintenance medications were being prescribed in accordance with the 2007 COPD guidelines of the Canadian Thoracic Society for patients admitted to hospital for acute exacerbation of COPD.Methods: A chart review was conducted for admissions to the Centre hospitalier universitaire de Sherbrooke, in Sherbrooke, Quebec, for acute exacerbation of COPD (according to diagnostic codes in the International Statistical Classification of Diseases and Related Health Problems, 10th revision) between January 1, 2008, and January 31, 2011. Data were extracted from patients’ medical charts concerning respiratory medications prescribed before the admission, during the hospital stay, and at discharge.Results: A total of 846 hospital admissions involving 561 patients were reviewed. In almost 70% of admissions for which data were available on respiratory medications prescribed before the admission, during the hospital stay, and at discharge (238/341 [69.8%]), a combination of 3 medications was prescribed at discharge: tiotropium, a long-acting ß2 agonist, and an inhaled corticosteroid. For more than 80% of the admissions, a prescription for at least one inhaled long-acting bronchodilator was documented both on admission and at discharge. Few patients had a prescription for inhaled corticosteroid without long-acting ß2 agonist, but the number of admissions with a prescription for regular use of systemic corticosteroids increased at discharge.Conclusions: Respiratory medications were generally prescribed in accordance with Canadian COPD guidelines, but improvements could be made regarding use of the combination of tiotropium, long-acting ß2agonist, and inhaled corticosteroid, as well as long-term use of systemic corticosteroids.RÉSUMÉContexte : L’exacerbation aiguë de la maladie pulmonaire obstructive chronique (MPOC) est associée à une réduction accélérée de la fonction pulmonaire et à un déclin notable de l’état de santé. Les médicaments respiratoires d’entretien peuvent réduire le risque d’une telle exacerbation.Objectif : Déterminer si les médicaments respiratoires d’entretien ont été prescrits conformément aux lignes directrices de 2007 de la Société canadienne de thoracologie pour la prise en charge de la MPOC chez les patients hospitalisés pour une exacerbation aiguë de la MPOC.Méthodes : Une analyse rétrospective des dossiers médicaux des patients hospitalisés au Centre hospitalier universitaire de Sherbrooke, à Sherbrooke (Québec), pour une exacerbation aiguë de la MPOC (d’après les codes diagnostiques de la Classification statistique internationale des maladies et des problèmes de santé connexes, 10e révision) entre le 1er janvier 2008 et le 31 janvier 2011 a été menée. Les renseignements sur les médicaments respiratoires qui ont été prescrits avant et pendant l’hospitalisation et au congé ont été extraits des dossiers médicaux des patients.Résultats : Un total de 846 admissions à l’hôpital intéressant 561 patients ont fait l’objet de l’analyse. Dans presque 70 % des admissions pour lesquelles on disposait des renseignements sur les médicaments respiratoires prescrits avant et pendant l’hospitalisation et au congé (238/341 [69,8%]), une combinaison de trois médicaments a été prescrite au congé : le tiotropium, un ß2-agoniste à action prolongée et un corticostéroïde en inhalation. Dans plus de 80 % des admissions, une ordonnance pour au moins un bronchodilatateur à action prolongée a été consignée à l’admission et au congé. Peu de patients avaient reçu une ordonnance pour un corticostéroïde en inhalation sans un ß2-agoniste à action prolongée, mais le nombre d’admissions pourvues d’une ordonnance pour un corticostéroïde systémique était plus élevé lors du congé.Conclusions : Les médicaments respiratoires ont été généralement prescrits conformément aux lignes directrices canadiennes pour la prise en charge de la MPOC, mais des améliorations pourraient être apportées concernant l’emploi du traitement associant le tiotropium, un ß2-agoniste à action prolongée et un corticostéroïde en inhalation, et l’utilisation à long terme d’un corticostéroïde systémique.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.045
Threshold uncertainty score0.089

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.275
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations7
Published2012
Admission routes3
Has abstractyes

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