THE CHANGING PATTERN OF PEDIATRIC IBD AT BRITISH COLUMBIA CHILDRENS HOSPITAL
Bibliographic record
Abstract
Background: Epidemiologic studies suggest an increase in incidence of Inflammatory Bowel Disease (IBD) in children. British Columbia Childrens Hospital (BCCH) is in a unique position as the only tertiary referral centre for pediatric patients in the province, with all practicing pediatric gastroenterologists at this site. Aim: To compare incidence and clinical characteristics of pediatric IBD patients referred to BCCH between 1990-1994 and 2000-2004. Methods: A retrospective chart review was undertaken with at diagnosis data collected from medical charts of all patients ≤16 years of age diagnosed with IBD at BCCH between 1990-1994 and 2000-2004. Data on age, gender, ethnicity, family history of IBD, type and extent of disease and surgical intervention was collected. Provincial population statistics were obtained from Statistics Canada. The diagnosis and classification of disease was based on standard clinical, endoscopic, radiological and histological criteria. Results: Seventy patients were diagnosed with IBD during 1990-1994, equivalent to an incidence rate 1.69/105 (1.18/105 for CD, 0.46/105 for UC and 0.05/105 for IC) in contrast to 298 patients diagnosed during 2000-2004, corresponding to an incidence rate of 7.21/105 (5.06/105 for CD, 1.14/105 for UC and 1.01/105 for IC). Twenty three percent of children diagnosed were ≤6 years (1990-1994) compared to 8.8 % (2000-2004), (OR 3.11, CI 1.56, 6,19), 24% were diagnosed with upper gastrointestinal disease vs. 40%, 24.3% had surgery vs. 8.1% (OR 3.662, CI 1.842, 7.282). No differences were observed in the male to female ratio, ethnic distribution, duration of symptoms prior to diagnosis, and family history from either cohort. Conclusions: Children diagnosed with IBD during 1990-1994 in BCCH tended to be younger, and more likely to undergo surgery. The 4-fold increase in incidence of IBD at BCCH likely reflects change in referral pattern in addition to an increase in incidence, whereas the increase in upper GI disease likely reflects a change diagnostic practice.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.005 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".